| QUANTITY | PRICE PER ITEM |
|---|---|
| 1 to 4 | $200.00 each |
| 5 to 9 | $180.00 each |
| 10 to + | $165.00 each |
CJC-1295 – No DAC (10 mg)
CJC-1295 – No DAC, also known as Modified GRF (1–29), is a synthetic analogue of growth hormone–releasing hormone (GHRH) engineered to enhance stability while preserving the natural pulsatile dynamics of growth hormone secretion. Through strategic amino acid substitutions, this 29-residue peptide resists rapid enzymatic degradation that typically limits endogenous GHRH, making it a valuable tool for studying controlled growth hormone release patterns and their downstream metabolic and anabolic effects in research settings.
Structural Profile
- Composition: A 29-amino-acid sequence (Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂) derived from the first 29 amino acids of native GHRH.
- Modification: Features four key substitutions—D-Ala at position 2, plus alterations at positions 8, 15, and 27—that dramatically improve resistance to dipeptidyl peptidase-IV (DPP-IV) degradation.
- Pharmacokinetics: Exhibits a half-life of approximately 30 minutes, supporting short-acting, pulsatile administration protocols that closely mimic endogenous GHRH physiology in experimental models.
Research Significance
Preclinical and early-phase human studies position CJC-1295 – No DAC as a selective GHRH receptor agonist that stimulates growth hormone release from the anterior pituitary in discrete, physiologically relevant pulses. This design preserves the natural rhythm of GH secretion without the sustained elevation seen with longer-acting analogues, offering researchers precise temporal control over hormonal dynamics.
Its short duration of action makes it particularly suited for combination protocols with growth hormone secretagogues (GHRPs), where synergistic effects on GH amplitude and metabolic endpoints have been documented. Research applications span investigations into lean tissue accretion, metabolic regulation, tissue repair mechanisms, and bone remodeling pathways—all mediated through the growth hormone–IGF-1 axis.
The peptide has demonstrated predictable dose-response characteristics and minimal off-target endocrine interference in controlled studies, establishing a favorable safety and specificity profile for experimental use. Its C-terminal amidation further contributes to biological activity and proteolytic resistance, reinforcing its utility in repeated-dosing research paradigms.
Citations
- PubChem Compound Summary: Modified GRF (1‑29), amino acid modifications for enhanced stability. Overview of Mod GRF (1‑29) / CJC‑1295 – No DAC
- J Clin Endocrinol Metab: “D-Ala2 incorporation increases half-life of GHRH-(1-29).” Overview of Mod GRF (1‑29) / CJC‑1295 – No DAC
- Biochem Biophys Res Commun: “Biological potency of GHRH and fragments.” Overview of Mod GRF (1‑29) / CJC‑1295 – No DAC
- Exploring-Peptides.com: “Mod GRF 1‑29 Peptide Profile – GH release, metabolism, tissue repair.” Overview of Mod GRF (1‑29) / CJC‑1295 – No DAC
Advanced Research Peptide: A highly stable synthetic heptapeptide designed for laboratory and academic research use.
High Purity & Stability: Built with the Pro-Gly-Pro (PGP) motif to resist enzymatic breakdown, enabling consistent results in experimental settings.
Neuroactive Properties: Its unique structure allows researchers to explore effects on neuroplasticity, gene expression, and molecular signaling pathways.
Molecular Precision: With a defined sequence (MEHFPGP) and confirmed molecular weight (813.9 Da), it offers reliability for controlled studies.
Versatile Application in Studies: Used to investigate areas such as cognitive processes, neurotransmitter activity, and cellular response to stress in preclinical models.
Backed by Published Research: Extensively studied in animal models and human volunteers for its influence on molecular and behavioral parameters (see citations).
We prioritize the highest safety standards for all our research products. Each compound is sourced from reputable laboratories and undergoes stringent quality checks before distribution. All items are intended strictly for in-vitro research purposes only and are not for human or animal consumption. Always handle these products using proper laboratory safety protocols.
Our products are produced and tested to ensure exceptional purity levels for research consistency. Every batch is analyzed using validated methods such as HPLC and mass spectrometry to confirm identity and quality. This rigorous approach ensures reliability and reproducibility in your scientific studies.
Always Quality-Tested, With proven results
Purity Verification
- Independent analysis confirming 99%+ purity for every batch.
Sterility Assurance
- Validated through sterile handling and testing protocols.
pH Balance Check
- Ensuring stability, consistency, and proper formulation standards.
Endotoxin Screening
- Rigorous checks to confirm compounds meet strict safety thresholds.
Why choose Elevated Vitality
Verified Purity
Every compound is third-party tested and verified 99%+ pure for consistency and reliability.
Made in USA
Manufactured under strict quality standards, ensuring trust and transparency at every step.
Transparent Pricing
No hidden fees, no subscriptions — straightforward access to premium formulations.
Seamless Experience
Fast, discreet shipping and a refined online ordering process designed for ease.
| Elevated Vitality Peptides | Typical Peptides Company | |
|---|---|---|
| Purity |
99%+ Verified Purity
|
Often Unverified
|
| Sourcing |
Made in USA, Strict Quality Controls
|
Overseas or Unclear Origins
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| Transparency |
Clear Pricing, No Hidden Fees
|
Markups, Hidden Costs
|
| Standards |
Research-Driven, Lab-Tested
|
Limited Testing or Oversight
|
| Experience |
Luxury Packaging & Premium Support
|
Generic Presentation
|
| Trust |
Built On Integrity & Consistency
|
Little Brand Accountability
|
