What is BPC-157 (5mg)?

BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide consisting of 15 amino acids, originally derived from a partial sequence of a naturally occurring protein found in human gastric juice. Since its discovery, it has been synthesized and studied in laboratory settings for its diverse biological properties, with a focus on tissue regeneration, gastrointestinal protection, and cellular defense mechanisms.

Unlike peptides that primarily act through endocrine pathways, BPC-157 has been investigated for its cytoprotective and restorative roles across a wide range of systems, including musculoskeletal, vascular, and gastrointestinal tissues. Preclinical studies highlight its unique stability—retaining activity in harsh gastric conditions and remaining viable under room temperature storage—which has made it a versatile candidate for experimental applications.

Chemical Structure of BPC-157

1. Peptide Class: Pentadecapeptide (15 amino acids)
2. Sequence: Gly–Glu–Pro–Pro–Pro–Gly–Lys–Pro–Ala–Asp–Asp–Ala–Gly–Leu–Val
3. Molecular Formula: C₆₂H₉₈N₁₆O₂₂
4. Molecular Weight: ~1,419.5 Da
5. Key Properties: High stability, resistance to enzymatic breakdown in gastric environments, adaptable to multiple routes of administration in research

Research Applications of BPC-157

1. Tissue Repair and Recovery – Experimental models show accelerated restoration of tendon, ligament, muscle, and skin integrity, often linked to increased collagen production and angiogenesis.
2. Gastrointestinal Support – BPC-157 has been widely studied for its protective influence on the digestive tract, including anti-ulcer activity and preservation of intestinal lining structure in injury models.
3. Vascular and Angiogenic Pathways – Preclinical data indicate activity in nitric oxide signaling and VEGF pathways, suggesting a role in blood vessel development and vascular adaptation to injury.
4. Neuroprotective and Organ Effects – Findings suggest potential protective responses in the central nervous system and organs such as the liver and kidneys under toxic or oxidative stress conditions.
5. Anti-Inflammatory and Antioxidant Activity – Research highlights a capacity to modulate cytokine activity, regulate nitric oxide, and reduce oxidative damage markers in stressed tissues.

Citations

1. PubChem, “BPC‑157 Compound Summary,” NCBI PubChem, CID 9941957. BPC‑157 Molecular Structure
2. Peptide Sciences, “What is BPC‑157 Peptide?” BPC‑157 Molecular Structure
3. Seiwerth S, et al. “Stable Gastric Pentadecapeptide BPC‑157 and Wound Healing.” Front Pharmacol. 2021;12:627533. BPC‑157 Molecular Structure
4. Staresinic M, et al. “BPC‑157 accelerates healing of rat Achilles tendon.” J Orthop Res. 2003;21(6):976–983. BPC‑157 Molecular Structure
5. Chang CH, et al. “BPC‑157 promotes tendon healing.” J Appl Physiol. 2011;110(3):774–780. BPC‑157 Molecular Structure
6. “Stable gastric pentadecapeptide BPC‑157: GI therapy.” Curr Pharm Des. 2011. BPC‑157 Molecular Structure
7. “BPC‑157 promotes angiogenesis via VEGFR2 and NO.” BPC‑157 Molecular Structure
8. Peptides.org, “BPC‑157 Reviews and Safety.” BPC‑157 Molecular Structure
9. Cerovecki T, et al. “BPC‑157 improves ligament healing in rats.” J Orthop Res. 2010;28(9):1155–1161. BPC‑157 Molecular Structure