| QUANTITY | PRICE PER ITEM |
|---|---|
| 1 to 4 | $200.00 each |
| 5 to 9 | $180.00 each |
| 10 to + | $165.00 each |
IGF-1 LR3 (1mg)
IGF-1 LR3 (Insulin-Like Growth Factor-1 Long Arg3) is a recombinant analogue of the naturally occurring human IGF-1 protein, engineered to improve metabolic stability, bioactivity, and receptor binding efficiency in research settings. It incorporates the complete 70-amino-acid sequence of native IGF-1 with two critical modifications: a glutamic acid to arginine substitution at position 3 (Arg3) and a 13-amino-acid N-terminal extension. These adjustments significantly reduce affinity for IGF-binding proteins (IGFBPs), prolong its half-life, and enhance receptor potency compared to the unmodified form.
Chemical Structure of IGF-1 LR3
- Sequence: 83 amino acids, including the Arg3 substitution and N-terminal extension
- Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
- Molecular Weight: ~9,117 Da
- Database Reference: PubChem CID (structure and sequence details)
Research Insights and Applications
- Extended Activity: With a reported half-life of approximately 20–30 hours, IGF-1 LR3 provides prolonged signaling compared to native IGF-1, which is rapidly sequestered by IGFBPs.
- Receptor Potency: Exhibits nearly three times greater bioactivity at the IGF-1 receptor, amplifying downstream signaling pathways such as PI3K/Akt and MAPK, both central to cell growth and metabolism.
- Cellular Proliferation: Frequently studied in models of protein synthesis, nitrogen retention, and cell cycle progression, where it plays a role in anabolic processes.
- Tissue and Regenerative Research: Used in experimental models of muscle, cartilage, nerve, and skin repair, with evidence of enhanced nutrient uptake and cellular resilience under stress.
- Metabolic Modulation: IGF-1 LR3 has been investigated for its ability to support glucose and amino acid utilization, making it a focus of metabolic research.
Citations
- PubChem Compound Summary – IGF‑1 LR3: molecular structure, Arg3 substitution, and formula Overview of IGF‑1 LR3
- Tomas FM, et al. “IGF‑I analogues show greater potency and prolonged effects.” J Endocrinol Overview of IGF‑1 LR3
- von der Thüsen JH, et al. “IGF‑1 enhances plaque stability in atherosclerosis.” Am J Pathol Overview of IGF‑1 LR3
- Mohan S, Baylink DJ. “IGF‑binding proteins and regulation of IGF activity.” J Endocrinol Overview of IGF‑1 LR3
- Tomas FM, Knowles SE, et al. “Anabolic effects of IGF‑I variants in rat models.” Biochem J Overview of IGF‑1 LR3
Advanced Research Peptide: A highly stable synthetic heptapeptide designed for laboratory and academic research use.
High Purity & Stability: Built with the Pro-Gly-Pro (PGP) motif to resist enzymatic breakdown, enabling consistent results in experimental settings.
Neuroactive Properties: Its unique structure allows researchers to explore effects on neuroplasticity, gene expression, and molecular signaling pathways.
Molecular Precision: With a defined sequence (MEHFPGP) and confirmed molecular weight (813.9 Da), it offers reliability for controlled studies.
Versatile Application in Studies: Used to investigate areas such as cognitive processes, neurotransmitter activity, and cellular response to stress in preclinical models.
Backed by Published Research: Extensively studied in animal models and human volunteers for its influence on molecular and behavioral parameters (see citations).
We prioritize the highest safety standards for all our research products. Each compound is sourced from reputable laboratories and undergoes stringent quality checks before distribution. All items are intended strictly for in-vitro research purposes only and are not for human or animal consumption. Always handle these products using proper laboratory safety protocols.
Our products are produced and tested to ensure exceptional purity levels for research consistency. Every batch is analyzed using validated methods such as HPLC and mass spectrometry to confirm identity and quality. This rigorous approach ensures reliability and reproducibility in your scientific studies.
Always Quality-Tested, With proven results
Purity Verification
- Independent analysis confirming 99%+ purity for every batch.
Sterility Assurance
- Validated through sterile handling and testing protocols.
pH Balance Check
- Ensuring stability, consistency, and proper formulation standards.
Endotoxin Screening
- Rigorous checks to confirm compounds meet strict safety thresholds.
Why choose Elevated Vitality
Verified Purity
Every compound is third-party tested and verified 99%+ pure for consistency and reliability.
Made in USA
Manufactured under strict quality standards, ensuring trust and transparency at every step.
Transparent Pricing
No hidden fees, no subscriptions — straightforward access to premium formulations.
Seamless Experience
Fast, discreet shipping and a refined online ordering process designed for ease.
| Elevated Vitality Peptides | Typical Peptides Company | |
|---|---|---|
| Purity |
99%+ Verified Purity
|
Often Unverified
|
| Sourcing |
Made in USA, Strict Quality Controls
|
Overseas or Unclear Origins
|
| Transparency |
Clear Pricing, No Hidden Fees
|
Markups, Hidden Costs
|
| Standards |
Research-Driven, Lab-Tested
|
Limited Testing or Oversight
|
| Experience |
Luxury Packaging & Premium Support
|
Generic Presentation
|
| Trust |
Built On Integrity & Consistency
|
Little Brand Accountability
|
