Tesamorelin (10 mg)

Overview

Tesamorelin is a synthetic peptide analogue of human growth hormone–releasing hormone (GHRH), consisting of 44 amino acids with a unique N-terminal trans-3-hexenoic acid modification. This structural adjustment enhances the peptide’s biological stability and receptor binding affinity, making it a valuable research compound for examining pituitary signaling and growth hormone dynamics. Acting as a GHRH receptor agonist, tesamorelin promotes pulsatile release of endogenous growth hormone (GH), thereby providing a model system for studying endocrine regulation, metabolic balance, and body composition in preclinical and clinical contexts.

Structure & Chemical Properties

1. Peptide Length: 44 amino acids.
2. Modification: N-terminal acylation with trans-3-hexenoic acid.
3. Molecular Formula: C₂₂₁H₃₆₆N₇₂O₆₇S.
4. Molecular Weight: ~5,136 Da.
5. Key Features: Structurally mirrors native GHRH with enhanced resistance to enzymatic degradation, improved receptor affinity, and extended activity in research models.

Research Background

Endocrine Axis Stimulation

1. Tesamorelin engages pituitary GHRH receptors to trigger the natural GH–IGF-1 cascade.
2. This preserves physiologic pulsatility while enabling controlled activation of downstream growth hormone signaling pathways.

Metabolic & Mitochondrial Studies

1. Research has connected GH–IGF-1 stimulation with markers of improved mitochondrial oxidative capacity and cellular bioenergetics.
2. Studies highlight its relevance in examining energy turnover and phosphocreatine recovery.

Body Composition & Fat Distribution

1. Clinical trials have explored tesamorelin for its ability to modulate fat metabolism, with particular focus on visceral adipose tissue reduction.
2. Investigations also point to improved lipid handling and reductions in ectopic fat accumulation.

Extended Research Applications

1. Beyond metabolism, tesamorelin has been studied in models of sarcopenia, neurocognitive aging, and protective endocrine regulation.
2. Its multi-faceted activity makes it a versatile tool in the study of hormonal, metabolic, and regenerative processes.

Areas of Scientific Interest

1. GHRH receptor agonism and GH–IGF-1 axis stimulation.
2. Mitochondrial bioenergetics and cellular oxidative function.
3. Fat metabolism and body composition regulation.
4. Cognitive aging, muscle function, and resilience pathways.

Citations

1. PubChem Compound Summary for Tesamorelin (CID 146681838): molecular formula C₂₂₁H₃₆₆N₇₂O₆₇S; MW 5,136 Da. Overview of Tesamorelin
2. Peptides.guide entry on Tesamorelin: 44-amino-acid GHRH analogue with trans‑3‑hexenoic acid N‑terminus. Overview of Tesamorelin
3. PeptideSciences Research Review: tesamorelin restores GH pulsatility to reduce visceral fat, modulate metabolism, and enhance liver health. Overview of Tesamorelin
4. Research Peptides summary: tesamorelin researched for GH and IGF‑1 stimulation, fat metabolism, muscle growth. Overview of Tesamorelin
5. C. Grinspoon et al. “The Effects of Tesamorelin on Phosphocreatine Recovery in Obese Subjects With Reduced GH.” J Clin Endocrinol Metab. 2014;99(1):338–343. PMID: 24142878. Overview of Tesamorelin
6. J. Falutz et al. “Effects of tesamorelin (TH9507), a growth hormone–releasing factor analog, in HIV‑infected patients with excess abdominal fat: a pooled analysis of two phase 3 trials.” J Clin Endocrinol Metab. 2010;95(9):4291–4304. PMID: 20656618. Overview of Tesamorelin